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Научно-практическая ревматология

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Влияние терапии генно-инженерными биологическими препаратами на костную ткань больных ревматоидным артритом

https://doi.org/10.14412/1995-4484-2014-669-677

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Аннотация

Представлены современные данные литературы о влиянии генно-инженерных биологических препаратов (ГИБП) на минеральную плотность кости, костный обмен и ремоделирование костной ткани при ревматоидном артрите (РА). Благодаря высокой эффективности эти препараты широко используются при лечении больных РА. Поскольку заметную роль в патогенезе РА играет локальная и генерализованная резорбция и деструкция костной ткани, изучение вопроса о влиянии ГИБП на костную ткань может представлять существенный интерес. При взаимодействии иммунной и костной систем под влиянием различных провоспалительных цитокинов происходит активация остеокластогенеза. Установлено, что ингибирование провоспалительных цитокинов не только уменьшает воспаление суставов, но и препятствует развитию локального и генерализованного остеопороза. В настоящем обзоре обсуждаются результаты этих работ и вопросы будущих исследований.

Об авторах

П. С. Дыдыкина
ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой, Москва, Россия 115522, Москва, Каширское шоссе, 34А
Россия


И. С. Дыдыкина
ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой, Москва, Россия 115522, Москва, Каширское шоссе, 34А
Россия


Е. Л. Насонов
ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой, Москва, Россия 115522, Москва, Каширское шоссе, 34А
Россия


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Для цитирования:


Дыдыкина П.С., Дыдыкина И.С., Насонов Е.Л. Влияние терапии генно-инженерными биологическими препаратами на костную ткань больных ревматоидным артритом. Научно-практическая ревматология. 2014;52(6):669-677. https://doi.org/10.14412/1995-4484-2014-669-677

For citation:


Dydykina P.S., Dydykina I.S., Nasonov E.L. IMPACT OF BIOLOGICAL THERAPY ON BONE IN PATIENTS WITH RHEUMATOID ARTHRITIS. Rheumatology Science and Practice. 2014;52(6):669-677. (In Russ.) https://doi.org/10.14412/1995-4484-2014-669-677

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ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)