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Научно-практическая ревматология

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Абатацепт при ревматоидном артрите: новая форма, новые механизмы, новые возможности

https://doi.org/10.14412/1995-4484-2015-522-541

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Аннотация

Ревматоидный артрит (РА) – системное аутоиммунное ревматическое заболевание, характеризующееся хроническим воспалением синовиальной оболочки суставов и широким спектром внесуставных (системных) проявлений, ключевую роль в патогенезе которого играет патологическая активация Т-клеток. Поэтому среди разнообразных подходов к патогенетической терапии РА особое место занимает разработка препарата абатацепт (АБЦ), избирательно блокирующего костимуляцию Т-клеток. В обзоре представлены новые данные, касающиеся эффективности и безопасности подкожной лекарственной формы, обсуждены механизмы его действия в отношении подавления синтеза аутоантител, восстановления нормальной функции Т-регуляторных клеток и т. д. Специально рассмотрены механизмы, обеспечивающие синергическое действие АБЦ и метотрексата при РА, перспективы персонифицированной медицины в ревматологии на примере АБЦ.

Об авторе

Е. Л. Насонов
ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой, Москва, Россия 115522 Москва, Каширское шоссе, 34А
Россия

директор ФГБНУ НИИР им. В.А. Насоновой, академик РАН, докт. мед. наук, профессор



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Для цитирования:


Насонов Е.Л. Абатацепт при ревматоидном артрите: новая форма, новые механизмы, новые возможности. Научно-практическая ревматология. 2015;53(5):522-541. https://doi.org/10.14412/1995-4484-2015-522-541

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Nasonov E.L. ABATACEPT FOR RHEUMATOID ARTHRITIS: A NOVEL FORMULATION, NEW MECHANISMS, NEW POSSIBILITIES. Rheumatology Science and Practice. 2015;53(5):522-541. (In Russ.) https://doi.org/10.14412/1995-4484-2015-522-541

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ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)