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Научно-практическая ревматология

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Роль лабораторных биомаркеров в прогнозировании эффективности терапии ритуксимабом при ревматоидном артрите (новые данные)

https://doi.org/10.14412/1995-4484-2017-295-303

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Аннотация

Ревматоидный артрит (РА) является наиболее частым и тяжелым хроническим воспалительным заболеванием суставов, приводящим к ранней инвалидизации и сокращению продолжительности жизни пациентов. В ряде работ продемонстрировано, что краткосрочный и долгосрочный прогноз заболевания гораздо более благоприятен при достижении ремиссии на ранних стадиях болезни, однако эффективность того или иного лекарственного препарата широко варьирует у разных пациентов, что связано с гетерогенностью самого заболевания и рядом других причин. В связи с этим по-прежнему актуальной остается проблема поиска биомаркеров, позволяющих осуществлять персонифицированный выбор схемы лечения в каждом конкретном случае.

Одним из эффективных и безопасных препаратов, применяемых в терапии РА, является ритуксимаб (РТМ), представляющий собой химерные моноклональные антитела к мембранному CD20 антигену В-клеток, вызывающие деплецию различных субпопуляций В-лимфоцитов. По сравнению с другими генно-инженерными биологическими препаратами, РТМ отличается длительной эффективностью одного курса терапии, сохраняющейся в течение 6 мес и более. В настоящее время в литературе представлено большое количество данных, посвященных роли клеточных и молекулярных биомаркеров в прогнозировании эффективности терапии РТМ при РА, часть из которых рассмотрены в данном обзоре. 

Об авторах

А. С. Авдеева
ФГБНУ «Научно- исследовательский институт ревматологии им. В.А. Насоновой», Москва
Россия

научный сотрудник лаборатории стандартизации терапии ревматических заболеваний 

канд. мед. Наук

115522 Москва, Каширское шоссе, 34А



Д. А. Кусевич
Институт профессионального образования ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России, Москва
Россия

кафедра ревматологии 

аспирант 1-го года кафедры ревматологии 

119991 Москва, ул. Трубецкая, 8, стр. 2 



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Для цитирования:


Авдеева А.С., Кусевич Д.А. Роль лабораторных биомаркеров в прогнозировании эффективности терапии ритуксимабом при ревматоидном артрите (новые данные). Научно-практическая ревматология. 2017;55(3):295-303. https://doi.org/10.14412/1995-4484-2017-295-303

For citation:


Avdeeva A.S., Kusevich D.A. THE ROLE OF LABORATORY BIOMARKERS IN PREDICTING THE EFFICIENCY OF RITUXIMAB THERAPY FOR RHEUMATOID ARTHRITIS: NEW EVIDENCE. Rheumatology Science and Practice. 2017;55(3):295-303. (In Russ.) https://doi.org/10.14412/1995-4484-2017-295-303

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ISSN 1995-4484 (Print)
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