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Научно-практическая ревматология

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Стратегия снижения дозы и отмены генно-инженерных биологических препаратов при ревматоидном артрите в стадии ремиссии

https://doi.org/10.14412/1995-4484-2018-99-106

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Аннотация

Рекомендации по ведению больных ревматоидным артритом (РА) предусматривают усиление терапии при недостаточной ее эффективности; в то же время при успешном достижении поставленной цели может обсуждаться вопрос о снижении интенсивности лечения. В рекомендациях EULAR предусматривается возможность уменьшения дозы и даже отмены генно-инженерных биологических препаратов (ГИБП), особенно при проведении сочетанной терапии ГИБП и базисными противовоспалительными препаратами (БПВП). Однако стратегия такого изменения терапии еще недостаточно четко определена. В данном обзоре мы хотели бы затронуть вопрос, касающийся не раннего, а развернутого РА у больных с необратимыми изменениями опорно-двигательного аппарата, длительно получающих БПВП и/или ГИБП. При достижении ремиссии решить вопрос о возможности снижения дозы или отмены препарата в таких случаях бывает сложнее, чем при раннем РА.

Об авторах

М. А. Котовская
ФГБНУ «Научноисследовательский институт ревматологии им. В.А.Насоновой».
Россия
Москва.


Н. Ю. Никишина
ФГБНУ «Научноисследовательский институт ревматологии им. В.А.Насоновой».
Россия
Москва.


Ю. А. Олюнин
ФГБНУ «Научноисследовательский институт ревматологии им. В.А.Насоновой».
Россия
Москва.


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Для цитирования:


Котовская М.А., Никишина Н.Ю., Олюнин Ю.А. Стратегия снижения дозы и отмены генно-инженерных биологических препаратов при ревматоидном артрите в стадии ремиссии. Научно-практическая ревматология. 2018;56(1):99-106. https://doi.org/10.14412/1995-4484-2018-99-106

For citation:


Kotovskaya M.A., Nikishina N.Y., Olyunin Y.A. STRATEGY FOR DOSE REDUCTION AND DISCONTINUATION OF BIOLOGICAL AGENTS IN RHEUMATOID ARTHRITIS REMISSION. Rheumatology Science and Practice. 2018;56(1):99-106. (In Russ.) https://doi.org/10.14412/1995-4484-2018-99-106

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ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)