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Научно-практическая ревматология

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Ангиотензины и ревматоидный артрит

https://doi.org/10.14412/1995-4484-2018-753-759

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Аннотация

В настоящее время хорошо изучена роль ренин-ангиотензиновой системы (РАС) в регуляции деятельности сердечно-сосудистой системы и поддержании водно-электролитного гомеостаза. Однако за последние десятилетия были идентифицированы новые компоненты РАС, позволяющие предполагать более широкий спектр ее потенциального воздействия на организм. Принципиально важной для ревматологов является возможность воздействовать на воспаление, в том числе и ревматоидное, посредством блокады образования ангиотензина (АТ) II с помощью эффектов АТ 1–7 и ингибиторов ангиотензинпревращающего фермента, а также подавления процессов ангиогенеза, в первую очередь, за счет снижения выработки эндотелиального фактора роста. Органопротективный и противовоспалительный потенциал лекарственных препаратов, уменьшающих выработку АТ, доказанный в экспериментах in vitro и in vivo, позволяет рассматривать их как ангиотропные средства первого ряда у пациентов с ревматоидным артритом, особенно при наличии сопутствующей артериальной гипертензии и/или нефропатии.

Об авторах

Н. М. Савушкина
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой».
Россия

младший научный сотрудник лаборатории ранних артритов.

115522 Москва, Каширское шоссе, 34А.



E. А. Галушко
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой».
Россия

ведущий научный сотрудник лаборатории ранних артритов.

115522 Москва, Каширское шоссе, 34А.



Н. В. Демидова
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой».
Россия

научный сотрудник лаборатории ранних артритов.

115522 Москва, Каширское шоссе, 34А.



А. В. Гордеев
ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой».
Россия

профессор, зав. лабораторией ранних артритов.

115522 Москва, Каширское шоссе, 34А.



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Для цитирования:


Савушкина Н.М., Галушко E.А., Демидова Н.В., Гордеев А.В. Ангиотензины и ревматоидный артрит. Научно-практическая ревматология. 2018;56(6):753-759. https://doi.org/10.14412/1995-4484-2018-753-759

For citation:


Savushkina N.M., Galushko E.A., Demidova N.V., Gordeev A.V. Angiotensins and rheumatoid arthritis. Rheumatology Science and Practice. 2018;56(6):753-759. (In Russ.) https://doi.org/10.14412/1995-4484-2018-753-759

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ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)