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Научно-практическая ревматология

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Психологический стресс и ревматоидный артрит – интерференция патогенетических механизмов

https://doi.org/10.14412/1995-4484-2019-83-90

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Аннотация

Проанализированы молекулярные механизмы развития нормального и патологического нейроэндокринного и иммунного адаптивного ответа на психологический (ментальный) стресс с точки зрения его возможной провоцирующей роли в развитии ревматоидного артрита (РА). При детальном анализе выявляется синергизм механизмов, провоцирующих развитие патологического антистрессового адаптивного ответа и РА. Возможно, у лиц группы риска развития РА минимальные и малозаметные для индивидуума стрессовые ситуации, периодически провоцирующие продолжительную продукцию провоспалительных цитокинов, могут, в конце концов, привести к развитию ревматического заболевания.

Об авторах

Н. О. Туаева
Казанская государственная академия – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)
Россия

научный сотрудник ЦНИЛ Казанской государственной академии, химик-эксперт центра биоаналитических исследований и молекулярного дизайна (ЦБИиМД) Первого МГМУ им. И.М. Сеченова, канд. биол. наук;

420012, Казань, ул. Муштари, 11;

119991, Москва, ул. Трубецкая, 8, стр. 2



А. Е. Носырев
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)
Россия

руководитель, канд. техн. наук;

119991, Москва, ул. Трубецкая, 8, стр. 2



И. Ренадино
Казанская государственная академия – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России; Laboratory of Immunology and Immunotherapy, INSERM U1227, Hospital Morvan, Centre Hospitalier Regional Universitaire (CHU) de Brest
Россия

профессор, старший научный сотрудник ЦНИЛ КГМА, заведующий лабораторией иммунологии и иммунотерапии Университета Бреста;

420012, Казань, ул. Муштари, 11;

2 Avenue Foch, CHRU Morvan, 29609 Brest, France




М. И. Арлеевская
Казанская государственная академия – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России
Россия

старший научный сотрудник, канд. мед. наук;

420012, Казань, ул. Муштари, 11



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Для цитирования:


Туаева Н.О., Носырев А.Е., Ренадино И., Арлеевская М.И. Психологический стресс и ревматоидный артрит – интерференция патогенетических механизмов. Научно-практическая ревматология. 2019;57(1):83-90. https://doi.org/10.14412/1995-4484-2019-83-90

For citation:


Tuaeva N.O., Nosyrev A.E., Renaudineau Y., Arleevskaya M.I. Psychological stress and rheumatoid arthritis – interference of pathogenetic mechanisms. Rheumatology Science and Practice. 2019;57(1):83-90. (In Russ.) https://doi.org/10.14412/1995-4484-2019-83-90

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ISSN 1995-4484 (Print)
ISSN 1995-4492 (Online)